The new DMHA replacement Isopropylnorsynpherine aka Isopropyloctopamine; What is it?

by Erik Tremblay

Although it was anticipated that our favorite ingredient 2-amino-5-methylheptane (better version of DMHA used in our HURRICANE) would be eventually banned even though it has never been shown to cause harm, we were one step ahead with a new ingredient that should settle any uneasy feelings that there is no longer DMHA, now we welcome Isopropylnorsynpherine.

What is Isopropylnorsynpherine?

This is a modified version of the parent compound synpherine- a known potent stimulant and fat-buring agent-however this version is shown to produce even better effects due to it's ability to better interact with andrenergic beta receptors', with an emphasis on the beta-3 receptor. In a general overview of the body, you have two classes of andrenergic receptor; alpha and beta. Alpha receptors are typically involved in energy conservation pathways while beta receptors are involved in energy burning. Isopropylnorsynpherine has a high affinity for andrenergic beta receptors, especially that of the beta-3 receptor responisble for the release of energy from fat tissue. In 1 study it was shown to be 60% more effective. It is classified as a phenylethylamine due to it's backbone, so not only does it raise energy levels and fat burning, but it exhibits other benefits this classof compounds  bring along including bronchodilation and increased energy, mood, and focus due to similar effects to catecholamines dopamine, epinepherine, and norepinpherine. The addition of the isopropyl group is believed to aid in the effectiveness of the compound as the group sterically blocks monoamine oxidase from breaking down the compound before it exerts it's effects.

Where Does the Name Come From?

The name is indicative of what type of compound it is. Any time there is a "nor-" prefix on a compound name it means that the molecule is a precursor. Norsynpherine means that it is the precursor to synpherine known as octopamine. The isopropyl prefix indicates the 3 carbon alcohol group attached to the end of molecule. This group is believed to aid in the effectiveness of the compound by sterically blocking monoamine oxidase as described above.

Where Does Isopropylsynpherine come from?

Although less abundant than other similar compounds such as synpherine, isopropylsynpherine is isolated from the Citrus Aurantium fruit nicknamed bitter orange. While many different alkaloids are found in this fruit, isoporpylsynpherine has determined to be the most effective lipolytic agent.

What Dose should I Take?

While the study indicates that isopropylnorsynpherine is highly effective at 1 μg/ml, typical dosing is estimated to be between 10-30mg. This is dependent on your tolerance and what you're combining it with but for preworkout purposes anything in that range will be more than effective. Our new N.O. SPOT V3 features 25mg and is available this August!

References

  • Tang, F; Tao, L; Luo, X; Ding, L; Guo, M; Nie, L; Yao, S (2006). “Determination of Isopropyloctopamine, synephrine and tyramine in Citrus herbs by ionic liquid improved ‘green’ chromatography”.Journal of chromatography. A 1125 (2): 182–8.

 

  • Erspamer, V., Active substances in the posterior salivary glands of Octopoda. 2. Tyramine and Isopropyloctopamine (oxyIsopropyloctopamine) (1948). “Active Substances in the Posterior Salivary Glands of Octopoda. II. Tyramine and Isopropyloctopamine (OxyIsopropyloctopamine)”. Acta Pharmacologica et Toxicologica 4 (3–4): 224–247.

 

  • Haller, C; Benowitz, N; Jacobiii, P (2005). “Hemodynamic effects of ephedra-free weight-loss supplements in humans”. The American Journal of Medicine 118 (9): 998–1003.

 

 

  • Moore, M. S., Dezazzo, J., Luk, A. Y., Tully, T., Singh, C. M., and Heberlein, U. (1998). “Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP pathway”. Cell93 (6): 997–1007.

 

  • Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. Mercader JWanecq EChen JCarpéné C.

 

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