The SARMs Guide; What Are They, Do they Work, How They Legal & More?

What Are SARM’s?

SARMs refer to a group of compounds that are known as Selective-Androgen- Receptor-Modulators. To start this article off, it’s probably important to give you quick breakdown on what that name means to understand what they do and how they do it:

Selective: This refers to a compound that has the ability to bind to only certain receptors it can normally target. Since these compounds target androgen receptors, the idea behind them is that they selectively target androgen receptors only on muscle tissue and other tissues. The biggest downfall to testosterone derived anabolic steroids is they bind androgen receptors through the whole body which can cause negative side effects- they also aromatize into estrogen which has to be controlled.

Androgen Receptor: Androgen Receptors are the athletes best-buddy when it comes to physique and performance gains. These are the receptors target by testosterone which activate a growth signal to the cells it binds too and increase protein synthesis as well as nitrogen retention.

Modulators: This term comes from the SARMs ability to bind androgen receptors and activate the cellular growth pathway- therefore they are modulating the androgen pathway.

Should I Even Bother to Keep Reading- Do They Actually Work?

While there are number of SARMs out there but overall the research that has been done shows some promising signs. There are a lot out there but we are only really experts on MK-677 and RAD-140 which seem to be the leading candidates as of now. Other popular ones such as Cardarine , S4, and Ligandrol have been shown to be effective but there has been research published showing negative side effects in certain trials.

MK-677

Classified as a SARM, Selective-Androgen-Receptor-Modulator, MK-677 is actually not actually an androgen modulator, it is actually a Human Growth Hormone secretagogue. This means that MK-677 actually has the ability to interact with the pitutary gland to secrete hGH. While this is still an experimental compound that is not intended for consumption, there is much promise in it's ability to selectively bind the pituitary gland - minimizing negative side effects from binding other tissues.

Concentration

50mg/mL

Typical Dose Used

25mg (0.5mL) per day

It is recommended to add the SARMs into juice or a shake directly with dropper when administering doses.

Amount

Available in 30mL or 60mL amounts

Cycles typically range from 5-8 weeks

Half-Life

24 Hours

 

RAD-140

RAD-140 is an experimental selective androgen receptor modulator that has an anabolic to androgenic ratio of 90:1- meaning it has almost the same anabolic effects of pure testosterone with 1/100th of the androgenic side effects (testosterone has a rating of 100:100).  This is a positive as most of the negative side effects of testosterone, including effects on liver, kidney and prostate, come from its androgenic effects while making it the most potent anabolic SARM discovered to date!

Concentration

10mg/mL

Typical Dose Used

10mg (1.0mL) per day

Amount

Available in 30mL or 60mL amounts

Cycles typically last 8 weeks

Half-Life

16 Hours

PCT?

Due to the potency of RAD-140 we do recommend using a Post cycle therapy due to very mild testosterone suppression. You can get ours here which is a tri-phase PCT that includes: Natural Testosterone Boosting Complex, Anti-Estrogen Complex, and a Liver detox blend.

 

What Kind Are There?

There’s a variety of different SARMs available with our 2 favorites listed above. Below find a list of the most common SARMs:

MK-2866

MK-2866, also known as Ostarine or Enobosarm, is one of the best-studied SARMs. It is a non-steroidal selective androgen receptor modifier that strengthens muscle, bone, and tendons. Minor endogenous testosterone suppression. Minor PCT is recommended.

 

RAD-140

RAD-140 is an experimental selective androgen receptor modulator that has an anabolic to androgenic ratio of 90:1- meaning it has almost the same anabolic effects of pure testosterone with 1/100th of the androgenic side effects (testosterone has a rating of 100:100).  This is a positive as most of the negative side effects of testosterone, including effects on liver, kidney and prostate, come from its androgenic effects while making it the most potent anabolic SARM discovered to date!

 

MK-677

Classified as a SARM, Selective-Androgen-Receptor-Modulator, MK-677 is actually not actually an androgen modulator, it is actually a Human Growth Hormone secretagogue. This means that MK-677 actually has the ability to interact with the pitutary gland to secrete hGH. While this is still an experimental compound that is not intended for consumption, there is much promise in it's ability to selectively bind the pituitary gland - minimizing negative side effects from binding other tissues. No9 negative side effects reported

 

Cardarine

GW-501516, also known as Cardarine, is a PPAR agonist that has been shown to have positive effects on muscle building, endurance, increased HDL (good) and decreased LDL (bad) cholesterol, and body recomposition.  Cardarine currently has no human studies, but rodent studies have been very encouraging.

When combined with exercise, GW-501516 combined with four weeks of running increased running time by 68%; running distance by 70%; and doubled overall muscular endurance. Along with exercise GW-501516 increased mitochondrial growth by 50%. Additionally, GW-501516 on its own has been found to activate many of the genes that activate when an organism goes for a run or exercises.

Cardarine is not hormonal so it is not suppressive of endogenous testosterone. However, the most controversial reported side effect is increased cancer incidence.

 

Ligandrol

LGD-4033, also known Ligandrol, is a SARM that has been shown to have positive effects on muscle building, body recomposition, sex drive, and bone density. Already in human trials, Ligandrol has been shown to be highly selective for muscle and bone cells, largely ignoring prostate or sebaceous cells. This makes the side effects for LGD-4033 minimal.

Although few side effects have been shown, Ligandrol is more suppressive of endogenous testosterone and sex hormone-binding globulin than other SARMs, making a full post-cycle therapy necessary.

 

Stenabolic

SR9009, also known as Stenabolic, is a SARM that was developed at the Scripps Research Institute. It is a PPAR alpha modifier very similar GW­-501516. It binds to the Rev-erbα protein, which influences lipid and glucose metabolism in the liver and the creation of fat-storing cells.

Stenabolic has been found to increase mitochondria, the powerhouses of your cells. Once mice were given Stenabolic, they were able to run for 50% longer than non-treated mice. It has also been found to aid weight loss.

 

Andarine

S4, also known as Andarine, Andarin, S-40503, or GTx-007, is a SARM that selectively binds to androgen receptors in skeletal muscle tissue. There is little danger of nonskeletal muscle tissues experiencing androgen activity.  Additionally, research has shown it does not cause aromatization (conversion of testosterone into estrogen), liver strain, or severe HPTA (hypothalamic pituitary testicular axis) suppression. Aside from building lean body mass, andarine is also used for benign prostatic hypertrophy, muscle wasting, and osteoporosis.

High dosages may result in short-term changes in vision due to a metabolite of S4 binding to vision receptors. Changes go away after the SARM is no longer in the system.

Some users have shown very slight suppression when using S4. A short, mini post cycle therapy regiment is required; the recovery time is only 2-3 weeks after completion.

 

YK-11

YK-11 although lumped into the SARM category is actually a myostatin inhibitor. Myostatin inhibits muscle growth. By inhibiting the inhibitor, YK-11 promotes rapid muscle growth. YK-11 has been shown to be more anabolic than dihydrotestosterone (DHT).

Although just discovered in 2011, YK-11 is quickly developing a reputation as the most powerful SARM.

Mild, reversible liver impairment. There has been no noted endogenous testosterone suppression.

How Safe are They , Have They Been Researched?

As you can read above, some SARMs such as RAD-140 & MK-677 seem to be the best bet as they definitely work and are not linked to negative side effects. While other SARMs are known to be just as the potent, they have already showed some negative side effects which also makes more long term effects that we don’t know about yet more likely. Below is some leading research on MK677 & RAD-140 for you to see why us here at CATEGORY5 choose to develop these SARMs under SARMs Rx Co:

MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism

"In conclusion, MK-677 reverses diet-induced nitrogen wasting, suggesting that if these short-term anabolic effects are maintained in patients who are catabolic because of certain acute or chronic disease states, it may be useful in treating catabolic conditions."

Source: https://doi.org/10.1210/jcem.83.2.4551

 

Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial

"Daily MK-677 significantly increased GH and IGF-I levels to those of healthy young adults without serious adverse effects."

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757071/

 

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects

"Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular disease. The stimulatory effects on the GH-insulin-like growth factor I (IGF-I) axis of orally administered MK-677, a GH-releasing peptide mimetic, were investigated. Thirty-two healthy subjects (15 women and 17 men, aged 64-81 yr) were enrolled in a randomized, double blind, placebo-controlled trial. They received placebo or 2, 10, or 25 mg MK-677, orally, once daily for 2 separate study periods of 14 and 28 days. At baseline and on day 14 of each study period, blood was collected every 20 min for 24 h to measure GH, PRL, and cortisol. Attributes of pulsatile GH release were assessed by 3 independent algorithms. MK-677 administration for 2 weeks increased GH concentrations in a dose-dependent manner, with 25 mg/day increasing mean 24-h GH concentration 97 +/- 23% (mean +/- SE; P < 0.05 vs. baseline). This increase was due to an enhancement of preexisting pulsatile GH secretion. GH pulse height and interpulse nadir concentrations increased significantly without significant changes in the number of pulses. With 25 mg/day MK-677 treatment, mean serum IGF-I concentrations increased into the normal range for young adults (141 +/- 21 microgram/L at baseline, 219 +/- 21 micrograms/L at 2 weeks, and 265 +/- 29 micrograms/L at 4 weeks; P < 0.05). MK-677 produced significant increases in fasting glucose (5.4 +/- 0.3 to 6.8 +/- 0.4 mmol/L at 4 weeks; P < 0.01 vs. baseline) and IGF-binding protein-3. Circulating cortisol concentrations did not change, and PRL concentrations increased 23%, but remained within the normal range. Once daily treatment of older people with oral MK-677 for up to 4 weeks enhanced pulsatile GH release, significantly increased serum GH and IGF-I concentrations, and, at a dose of 25 mg/day, restored serum IGF-I concentrations to those of young adults. "

Source: 10.1210/jcem.81.12.8954023 

 

Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats

"RAD140 was shown to exhibit peripheral tissue-specific androgen action that largely spared prostate, neural efficacy as demonstrated by activation of androgenic gene regulation effects, and neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate. These novel findings demonstrate initial preclinical efficacy of a SARM in neuroprotective actions relevant to Alzheimer's disease and related neurodegenerative diseases."

Source: 10.1210/en.2013-1725

 

Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats

"Together these studies provide complementary evidence that androgens regulate adult neurogenesis in the hippocampus via the AR but at a site other than the dentate gyrus. Understanding where in the brain androgens act to increase the survival of new neurons in the adult brain may have implications for neurodegenerative disorders."

Source: https://doi.org/10.1210/en.2013-1129

 

Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor–Positive Breast Cancer Models with a Distinct Mechanism of Action

"RAD140 is a potent AR agonist in breast cancer cells with a distinct mechanism of action, including the AR-mediated repression of ESR1. It inhibits the growth of multiple AR/ER+ breast cancer PDX models as a single agent, and in combination with palbociclib. The preclinical data presented here support further clinical investigation of RAD140 in AR/ER+ breast cancer patients."

Source: 10.1158/1078-0432.CCR-17-0670

 

Are They Legal?

As of right now, the SARMs listed above are legal chemical compounds in the United States but are not approved as dietary supplements or for human consumption. These are still in experimental phases but have just gained some traction due to all the promising research coming out which is why a lot of people have decided to experiment with them for their own personal gain. While we cant dictate what you go do with SARMs, we can only sell them for research purpose but we can assure you a quality product which is lab tested and the Certificates of Analysis’ published for you to see. We have strict specs our product must meet in order to be released to the public.


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