What is L-Citrulline and What is the Difference Between L-Citrulline and Citrulline Malate?

by Erik Tremblay

L-Cirtulline is one of the three dietary amino acids that are involved in the urea cycle working in conjunction with L-Arginine and L-Ornithine. In your kidneys, the Citrulline is converted into the products L-Arginine and nitric oxide. Nitric oxide is critical in increasing physical performance as it relaxes blood vessles, helping them to dilate and force oxygen and nutrient rich blood to the muscles delaying fatigue and aiding repair. Supplementation of L-Citrulline increases L-Arginine and L-Ornithine plasma levels (form of it in blood) improving the recycling of ammonia in the urea cycle and aiding the nitric oxide metabolism. We prefer larger supplementation doses of L-Cirtulline over L-Arginine however because of L-Citrulline’s ability to increase Arginine plasma levels over a longer period of time and not having a dose where it can no longer be absorbed leading to diarrhea. This can be the case in large doses of L-Arginine.

In many cases you will find that Citrulline Malate is used, but what exactly is the difference? Well, Citrulline Malate still contains the normal L-Citrulline molecule responsible for the vasodilating effects (opening of blood vessels), however it is combined with malic acid; this is where the “Malate” comes from. The ratio next to the ingredient name is the ratio as to how many molecules of Citrulline there are as compared to malic acid, and that ratio should always favor Citrulline as a smaller dose of Malic Acid is needed than Citrulline. This is why we use Citrulline Malate 2:1 meaning that for every one molecule of malic acid there is, there is two Citrulline molecules. Now, how does Malic Acid work?

Malic Acid- a dicarboxylic acid that is used to help delay fatigue as it is in intermediate in the cellular energy producing cycle known as the Kreb’s cycle .The Kreb’s cycle is one of the three mechanisms of cellular respiration, which is the process of producing the energy packed molecule of Adenine-Tri-Phosphate (ATP) which is the basis of energy in your cells. During the cycle, Malate is formed by adding H2O to a fumerate molecule which is then oxidized by NAD to eventually form oxaloacetate , which can combine with acetyl-cozyme A and begin the energy producing process all over again. So having a source of malic acid allows the krebs cycle to keep gong and generating more ATP from the breakdown of carbohydrates, fats, and proteins. In some of our products we use citrulline malate to give the additional benefits of helping to boost energy, however when the product already contains efficient amounts of other fatigue delaying compounds, we use pure L-Citrulline to get the maximum amount of PUMP possible. Since N.O. SPOT contains 3 different vasodilators, including an unheard dose of 4g of beta alanine , we use citrulline malate as the malic acid is more needed in providing energy than the citrulline is (definitely still want some though which is why we didn’t put pure malic acid). However, in HURRICANE, since the pre-workout dose already has 8g of BCAAs in a 6:1:1 ratio and two energy sources of 2-Amino-5-Methylheptane and TeaCrine®, the malic acid is as not as important, so we included just pure L-Citrulline for maximum PUMP effects!

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