Most of us know, or have at least experienced, the great effects of L-Citrulline and L-Arginine in relation to muscular pumps. These amino acids are involved in the nitric oxide cycle, eventually being metabolized into the performance enhancing vasodilating compound. While these are critical components of any performance enhancement product, theres an incredibly important third player that can make these compounds even more effective- hello, L-Norvaline.
What is L-Norvaline and how does it work?
L-Norvaline is a modified version of the BCAA Valine, but it contains an additional hydrogen in its back bone. This slight modification creates a pretty potent affinity for an enzyme in your body called Arginase. This enzyme is involved in limiting the amount of nitric oxide that can be produced from Arginine-typically when you supplement with arginine most of it is broken down to urea before it ever becomes nitric oxide. Supplementing with Norvaline increases the efficiency of Arginine by inhibiting that enzyme from breaking it down. This is most effective as Arginine is the only amino acid that is the direct precursor to Nitric Oxide, Citrulline malate is involved in the process but doesn't actually contribute to production until it is recycled into Arginine.
What is the optimal dose?
L-norvaline is pretty well studied and there's valid research showing it as an effective nitric oxide booster in ranging doses from 100-300mg, which is our N.O. SPOT contains 300mg in conjunction with 6g Citrulline Malate and 2g Arginine AKG. The arginine in theory acts quicker than the Citrulline, and the norvaline blocks the enzyme involved in the breakdown of the needed arginine to waste, causing the production of nitric oxide to be maximized.