What You Don’t Know About Stimulants and How You Can Get Better Effects; A Focus On Phenylethylamine

by Erik Tremblay

We formulated the new RIPTIDE V2 as a potent thermogenic that has a combination of both methylxanthine and monamine class compounds to produce energy, focus, performance, and fat loss like you’ve never experienced. These compounds work synergestically together to form the ultimate sustained energy blast.

Effects You Can Expect To Experience From Supplementing With Phenylethylamine:

  • Increase In Positive Mood From Increased Dopamine and Serotonin Levels
  • Greatly Enhanced Energy and Focus From Adrenaline Reuptake
  • Mind-Blowing Focus from Acetylcholine Release
  • Fat Loss From An Increase In Calories Being Burned

Energy and Focus are two of the most important parts when it comes to achieving the goals you have in mind for yourself, especially when it comes to training. Many of us work demanding jobs so we look for energy boosts throughout the day and specifically before a workout, we also live in a society where our phones keep us constantly plugged in and focusing on every rep and aspect of our workouts can be challenging. This leaves most of us to rely on caffeine to solely power us through, soon building a tolerance, and just consuming more and more even up to unsafe amounts which will soon have diminishing effects. We understand and have experienced that same process which is why we are always discovering and introducing to you guys different classes of compounds that not only work to greatly enhance energy and focus like caffeine, but also help to enhance caffeine’s effects and eliminate tolerance. There are two main classes of compounds that do this most effectively: Xanthines and Monoamines.

Xanthines

Xanthines are a class of organic compounds that are derived from the purine base xanthine. Xanthine itself is found in most body fluids and organs, and gives rise to a number of compounds the include some of the most effective and common stimulants we know, such as caffeine and theobromine which are known as methylxanthines due to the presence of methyl groups (CH3-red on the diagram) on the NH groups on the Xanthine structure. If you look above you will notice the only differences between xanthine, caffeine, and theobromine is the addition of methyl groups to the structure; theobromine having two and caffeine having three. These methyl groups are significant because they are attached to the NH groups on the structure which allows them to exert potent stimulant properties in two different ways:

  • Phosphodiesterase Inhibitors: They can bind to and block the enzyme phosphodiesterase to raise cAMP and activate PKA (Protein Kinase A- an enzyme directly involved in the metabolism of fats, proteins, and carbs which is why they exert great fat loss abilities) and also regulate certain immune system aspects such as TNF-α and Leukotriene concentrations to reduce inflammation and other innate immunity effects; this gives them their bronchodilation effects(Opening of air passageways)
  • Adenosine Receptor Antagonists: basically, methylxanthines can also bind to adenosine receptors to block the receptor from being stimulated. Adenosine is a neuromodulator responsible for the onset of fatigue and drowsiness, but if the receptor needed for adenosine to bind to for it to exert its effects is blocked by the presence of one of the methylxanthine compounds, the fatigue will not occur.
  • There have also been findings that show methylxanthines have the ability to block an enzyme (monoamine oxidase) responsible for the breakdown of various beneficial neurotransmitters such as dopamine and serotonin. The blocking of this enzymes is also why taking caffeine/theobromine with the next class of compounds were going to discuss, monoamines, is so effective.(1)

Monoamines

Since methylxanthines are extremely common and are susceptible to tolerance, we have began to introduce you guys to monoamines. All of our energy products contain monoamines as they are so effective in promoting energy, focus, and bronchodilation in other ways than the caffeine and are so underused in the industry due to their high cost. Monoamines contain 1 Amine (NH1, NH2, or NH3) group and are used to increase reuptake and levels of monoamine neurotransmitters we listed before(dopamine, adrenaline, serotonin) to produce extreme effects. They are derived from amino acids that contain an aromatic ring (rings with alternating double bonds which are significant because they can shift them around); these amino acids include; tryptophan, Tyrosine, and Phenylalanine. A derivative of phenylalanine is what is contained in our new RIPTIDE V2 so we will be focusing on that today.

For A More In Depth Look at Monoamines and How the 2-Amino We Use In Our HURRICANE Is Different and Way More Effective and Healthier Than Any Out There, Visit Our Monoamine Article Here

PHENYLETHYLAMINE HCl

Phenylethylamine is another cool compound we're excited to bring to you guys due to it's potent effects in generating similar effects to caffeine but more effectively. Phenylethylamine is what’s called a trace amine, meaning that it is monoamine that works on certain neurotransmitting receptors as an agonist (stimulates it) but is found in much smaller amounts than regular monoamines. To first get an idea of the compound let’s breakdown its name:

  • Phenyl is a term used to describe a derivative of a benzene ring (a benzene ring is a cyclic ring that has the formula C6H6 and has the alternating double-bonds that allows it to shift them around the ring). However, a benzene ring that has 1 less hydrogen is known as a phenyl group, this loss of a hydrogen is usually due to the presence of something attached to the ring, like another functional group(in this case being the ethyl group with the amine attached on the end)
  • Ethyl is a term given to a group with the formula CH2CH3. In order to get an understanding of what an Ethyl group is, relate it to the methyl groups we were talking about before. When there is a methyl group that is one carbon sticking out on the chain while an Ethyl Group is 2 carbons in a chain sticking out. In Phenylethylamine, the ethyl group is the two carbons sticking off the phenyl ring
  • Amine, the term we noted on before, is the presence of either an NH1, NH2, or NH3, group in a molecule. These are significant as Nitrogen is used in the body for a series of critical processes ranging from protein synthesis to the synthesis of neurotransmitters. Amino acids provide the nitrogen for protein synthesis while monoamine compounds influence neurotransmitter levels. The Amine group (NH2) is located on the end of the Ethyl part of the molecule.

This structure is significant because it allows Phenylethylamine to be a highly stable monoamine compound and exert strong effects. The presence of the phenyl ring on the compound allows it to more effectively cross the blood brain barrier. This ring is highly stable, and like I said, can shift its bonds around the ring to produce highly stably structures in what is known as resonance. Once in the brain, this compound can produce highly beneficial effects by influencing neurotransmitter levels.

Phenylethylamine is an intermediate that is converted into an isomer of amphetamine (Adderall) known as N-Methylphenethylamine by the enzyme phenylethanolamine N-methyltransferase (PNMT). This compound works the same as any monoamine, just in a different potency, to increase reuptake of critical neurotransmitters Dopamine, Serotonin, Adrenaline, etc. For a more broken down version of that process visit our blog on monoamines here.(2)

Combining both these classes of compounds produces effects like you’ve never experienced. The adenosine blocking + the blocking of Phosphodiesterase of the caffeine in conjunction with the neurotransmitter ruptake effects of the Phenylethylamine is second to none. If instant effects are what you’re looking for RIPTIDE V2 is what you need to experience.

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