The Most Effective Trademarked Probiotic Our Makzyme-Pro™ digestive aid contains the trademarked Makzyme-Pro™ enzyme blend in conjunction with other scientifically effective probiotics to bring you the best possible results. Working together, the combination of these enzymes with probiotics maximizes digestive function.
Makzyme-Pro can be taken by any individual but is specifically formulated for those who consistently experience a form of indigestion or irregularities that cause discomfort and other health problems. Makzyme-Pro helps break down your food into absorb-able macro nutrients that are easily processed by your digestive system. This makes it a great choice for athletes looking to help increase absorption of nutrients as well. We recommend taking 1 capsule in the morning and 1 at night about 20-30 minutes prior to a meal to keep your digestion regulated around the clock
Containing both a combination of probiotics and enzymes, Makzyme-Pro covers all aspects of any diet when it comes to easing the workload on your digestive system. Probiotics serve to maximize the growth of the good bacteria in your digestive tract while the specialized enzymes actively break-down your food to be utilized for different functions. Take a look at the different ingredients we blended into Makzyme-Pro™ to deliver the top digestive aid on the market:
As pictured above, our Makzyme-Pro™ contains a series of actual enzymes that actively contribute to helping your body break down your food into usable forms of macro nutrients:
These are protease enzymes isolated from Aspergillus oryzae that break down proteins into individual amino acids which your body can utilize to build proteins needed for growth and repair
These are lipase enzymes isolated from various fungus' that break down fats into fatty acids and cholesterol for your body to use to build different steroid hormones and other critical cellular components such as the membrane where fats are critical
These are lactase enzymes isolated from various fungus' that break down lactose by hydrolysis to become glucose or galactose- a useable form of energy for the body. This is very helpful for those sensitive to dairy compounds which are typically high in lactose
Known as a glycoprotein, alpha galactosidase catalyzes an important reaction of hydrolyzing glycolipids and proteins found in complex sugars that are typically harder for us to digest
Mixture of protein digesting enzymes from pineapple plants
Protease enzyme isolated from papaya
In conjunction with actively working enzymes, Makzyme-Pro also contains probiotics to improve your own gut biome:
A species of gram-positive bacteria that are homofermentive + microaerophillic- fermenting sugars into lactic acid. Studies have shown L. acidophilus to decrease circulating cholesterol levels and increase the amount excreted.
Complements L. acidophilus by improving it's growth and contributing to amylase enzyme concentration. This enzyme is responsible for breaking down starches from plants which can be challenging as our bodies do not produce the saccharides amylose/amylopectin
A potent anti-oxidant and regulator of intestinal permeability to aid absorption of nutrients
"Based on ELISA results and histological findings, a reduction of inflammation was observed. The group which was only exposed to L. rhamnosus and the one which was exposed to all three strains of Lactobacillus showed the highest antimicrobial effect on H. pylori.""According to the results of this study, probiotic bacteria including L. acidophilus, L. plantarum, and L. rhamnosus could be useful in the reduction of H. pylori infection in the mouse model."
Citation: Asgari, B., Kermanian, F., Hedayat Yaghoobi, M., Vaezi, A., Soleimanifar, F., & Yaslianifard, S. (2019). The Anti-Helicobacter pylori Effects of Lactobacillus acidophilus, L. plantarum, and L. rhamnosus in Stomach Tissue of C57BL/6 Mice. Visceral Medicine, 36(2), 137–143. doi: 10.1159/000500616
The gastrointestinal tract of mammals hosts a high and diverse number of different microorganisms, known as intestinal microbiota. Many probiotics were originally isolated from the gastrointestinal tract, and they were defined by the Food and Agriculture Organization of the United Nations (FAO)/WHO as "live microorganisms which when administered in adequate amounts confer a health benefit on the host." Probiotics exert their beneficial effects on the host through four main mechanisms: interference with potential pathogens, improvement of barrier function, immunomodulation and production of neurotransmitters, and their host targets vary from the resident microbiota to cellular components of the gut-brain axis. However, in spite of the wide array of beneficial mechanisms deployed by probiotic bacteria, relatively few effects have been supported by clinical data. In this regard, different probiotic strains have been effective in antibiotic-associated diarrhea or inflammatory bowel disease for instance. The aim of this review was to compile the molecular mechanisms underlying the beneficial effects of probiotics, mainly through their interaction with the intestinal microbiota and with the intestinal mucosa. The specific benefits discussed in this paper include among others those elicited directly through dietary modulation of the human gut microbiota.
Citation: Sánchez, B., Delgado, S., Blanco-Míguez, A., Lourenço, A., Gueimonde, M., & Margolles, A. (2016). Probiotics, gut microbiota, and their influence on host health and disease. Molecular Nutrition & Food Research, 61(1), 1600240. doi: 10.1002/mnfr.201600240
We found significantly increased amounts of SI, LPH, and ApN in colonocytes in most SBS patients with large variation and strongest effect for SI and ApN. Digestive enzyme expression was only partially elevated in duodenal enterocytes due to a low proliferation level measured by Ki-67 staining. Microbiome analysis revealed high amounts of Lactobacillus resp. low amounts of Proteobacteria in SBS patients with preservation of colon and ileocecal valve. Colonic expression was associated with a better clinical course in single cases. In SBS patients disaccharidases and peptidases can be upregulated in the colon. Stimulation of this colonic intestinalization process by drugs, nutrients, and pre- or probiotics might offer better therapeutic approaches.
Citation:Laffolie, J., Sheridan, D., Reinshagen, K., Wessel, L., Zimmermann, C., Stricker, S., … Zimmer, K. P. (2020). Digestive enzyme expression in the large intestine of children with short bowel syndrome in a late stage of adaptation. The FASEB Journal, 34(3), 3983–3995. doi: 10.1096/fj.201901758rr
All CATEGORY5™ products are manufactured in an UL NPA certified, FDA Inspected cGMP (Current Good Manufacturing Practice) certified facility. This ensures that our facilities comply with all Current Up To Date Food and Drug Administration regulations and requirements for the manufacturing of our supplements. Every single raw material used in our products is identity tested before production at a minimum and all finished products are submitted to rigorous quality control and assurance processes and procedures prior to being released to our Products. Guaranteeing the quality and safety of every bottle of CATEGORY5™ product continues to be at the core of our business and our vision.
*cGMP refers to the Current Good Manufacturing Practice regulations enforced by the US Food and Drug Administration (FDA). CGMPs provide for systems that assure proper design, monitoring, and control of manufacturing processes and facilities