Mushrooms have been a staple of traditional herbal medicine for thousands of years due to their beneficial properties and it’s important to understand why. Various species have been incorporated into different cultures as either foods such as Shiitake and Maitake or tea such as Chaga or Reishi . These mushrooms along with other fungal extracts we've included in this formula are packed with immune boosting, heart and brain powering nutrients. Powered by Chaga mushrooms, this formula contains the ever important anti-viral extract shown to impede and even prevent transmission of viral infections (9)
Mushrooms are the fruiting part of fungus' that contain spores as a reproduction mechanism for the species. The majority of fungi sprout what we call "Mushrooms" , and they are typically bright in color while containing a vast array of nutrients to attract organisms for reproduction. All of our extracts are taken from the fruiting body itself, to ensure that it is only the most nutrient packed portion of the fungi. Watch out for other mushroom products that don't ensure they extract their ingredients from the fruit. Among these nutrients are unique compounds shown to increase immune function, such as beta-glucans and Vitamin C + Zinc.
Mushrooms are typically packed with the following nutrients which give them their anti-cancer, anti-inflammatory, immune and mental boosting characteristics:
A constituent of fungal cell walls and especially found in one of the extracts contained in our formula- Turkey Tail Mushroom, these bioactive compounds are polysaccharides made up of B-D-glucose monomers that contain a unique 1-3 glycosidic bond (the first monosaccharide is bonded to the third), compared to the normal 1-4 typically found in other polysaccharides (1). Beta-glucans have been found to stimulate the immune system by enhancing macrophage and Natural Killer Cells efficacy (2)
Comprised of the compound riboflavin, Vitamin B2 is essential for several processes in the body. It is utilized by the body to make flavoproteins; a class of enzymes that include coenzymes of either Flavin MonoNucleotide (FMN) or Flavin Adenine Dinucleotide (FAD). These are extremely important contributors in producing ATP as they regularly accept and donate electrons. Without Vitamin B-2, they cannot be produced. Supplementing with vitamin B-2 is an easy way to optimize this process (3).
Known as Niacin, is an essential compound for humans. It is a precursor to the coenzymes Nicotinaminde Adenine Dinucleuotide (NAD) and Nicotinamide Adenine Dinucleotide Phosphate (NAPH). Very similar to the coenzymes discussed before, they also accept and donate electrons. All of these molecules are essential for the breakdown of fats, carbs, protein, alcohol, and even processes such as DNA repair (4).
Vitamin B-5: known as pantothenic acid, this compound is needed from our diets in order for us to synthesize another coenzyme called Coenzyme A (CoA). This is required for the oxidation reactions of fatty acids and pyruvate which is involved ATP production (5).
Also known as ascorbic acid, Vitamin C is an essential nutrient that we rely on our food sources for. While also being a strong antioxidant, vitamin c is utilized in many enzymatic reactions in the body and is utilized by the immune system for lymphocyte proliferation and antimicrobial properties (6).
Zinc is an element that we require from our diets and has strong antioxidant properties. When combined with Vitamin C, it is shown to have immune boosting characteristics (6).
Selenium: Selenium is a an element utilized as a micronutrient in which we require to form certain cofactors for the reduction of antioxidant enzymes. (7)
A vital electrolyte our bodies require to maintain a balance with sodium to control muscle movements through neuron depolarization (8).
Immune-enhancing role of vitamin C and zinc and effect on clinical conditions
"The present paper is intended to give an overview on the roles of vitamin C and Zn in immune functions. Vitamin C concentrations in theplasma and leucocytes rapidly decline during infections and stress. Supplementation of vitamin C improves components of the humanimmune system such as antimicrobial and natural killer (NK) cell activities, lymphocyte proliferation, chemotaxis and delayed-typehypersensitivity. Vitamin C contributes to maintaining the redox integrity of cells and thereby protects them against reactive oxygenspecies generated during the respiratory burst and in the inflammatory response. Similarly, Zn deficiency impairs cellular mediators ofinnate immunity such as phagocytosis, NK cell activity, and the generation of oxidative burst. Thus, both nutrients play important andcomplementary roles in immune function and the modulation of host resistance to infectious agents, reducing the risk, severity andduration of infectious diseases."
Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells.
"The tumor-killing mechanisms available to monoclonal antibodies (mAbs; e.g., antagonism of growth factor receptors, antibody-dependent cell-mediated cytotoxicity) limit efficacy. Previous studies suggested that i.v. beta-glucan might function as an adjuvant for antitumor mAbs. beta- Glucan had been shown to function via the iC3b-receptor complement receptor 3 (CR3; CD11b/CD18) thereby enhancing leukocyte killing of tumor cells coated with iC3b via naturally occurring antitumor antibodies. Therapy with beta-glucans was limited by levels of natural antibodies and by tumor escape through elimination of antigen-positive cells. Accordingly, it was hypothesized that beta-glucan responses could be improved by combined administration with antitumor mAbs. Five tumor models were explored in BALB/c or C57Bl/6 mice using tumors that expressed either high levels of naturally occurring antigens (e.g., G(D2) ganglioside) or recombinant human MUC1. In comparison with antitumor mAb or beta-glucan alone, combined treatment with mAb plus beta-glucan produced significantly greater tumor regression in all models that included mammary, s.c., and hepatic tumors. Tumor-free survival only occurred in models that incorporated stable expression of the target antigen. beta-Glucan enhancement of the mAb tumoricidal response did not occur in mice deficient in either leukocyte CR3 (CD11b(-/-)) or serum C3, confirming the requirement for CR3 on leukocytes and iC3b on tumors. Granulocytes appeared to be primarily responsible for tumoricidal activity, because beta-glucan therapeutic responses did not occur in granulocyte-depleted mice. These data suggest that the therapeutic efficacy of mAbs known to activate complement (e.g., Herceptin, Rituxan, and Erbitux) could be significantly enhanced if they were combined with beta-glucan."
Effects of beta-glucans on the immune system.
"Beta-glucans are naturally occurring polysaccharides. These glucose polymers are constituents of the cell wall of certain pathogenic bacteria and fungi. The healing and immunostimulating properties of mushrooms have been known for thousands of years in the Eastern countries. These mushrooms contain biologically active polysaccharides that mostly belong to group of beta-glucans. These substances increase host immune defense by activating complement system, enhancing macrophages and natural killer cell function. The induction of cellular responses by mushroom and other beta-glucans is likely to involve their specific interaction with several cell surface receptors, as complement receptor 3 (CR3; CD11b/CD18), lactosylceramide, selected scavenger receptors, and dectin-1 (betaGR). beta-Glucans also show anticarcinogenic activity. They can prevent oncogenesis due to the protective effect against potent genotoxic carcinogens. As immunostimulating agent, which acts through the activation of macrophages and NK cell cytotoxicity, beta-glucan can inhibit tumor growth in promotion stage too. Anti-angiogenesis can be one of the pathways through which beta-glucans can reduce tumor proliferation, prevent tumor metastasis. beta-Glucan as adjuvant to cancer chemotherapy and radiotherapy demonstrated the positive role in the restoration of hematopiesis following by bone marrow injury. Immunotherapy using monoclonal antibodies is a novel strategy of cancer treatment. These antibodies activate complement system and opsonize tumor cells with iC3b fragment. In contrast to microorganisms, tumor cells, as well as other host cells, lack beta-glucan as a surface component and cannot trigger complement receptor 3-dependent cellular cytotoxicity and initiate tumor-killing activity. This mechanism could be induced in the presence of beta-glucans."
All CATEGORY5™ products are manufactured in an UL NPA certified, FDA Inspected cGMP (Current Good Manufacturing Practice) certified facility. This ensures that our facilities comply with all Current Up To Date Food and Drug Administration regulations and requirements for the manufacturing of our supplements. Every single raw material used in our products is identity tested before production at a minimum and all finished products are submitted to rigorous quality control and assurance processes and procedures prior to being released to our Products. Guaranteeing the quality and safety of every bottle of CATEGORY5™ product continues to be at the core of our business and our vision.
*cGMP refers to the Current Good Manufacturing Practice regulations enforced by the US Food and Drug Administration (FDA). CGMPs provide for systems that assure proper design, monitoring, and control of manufacturing processes and facilities