Testolone & Nutrobal Stack: RAD-140 & MK-677 by SARMs Rx
Testolone & Nutrobal Stack: RAD-140 & MK-677 by SARMs Rx
Testolone & Nutrobal Stack: RAD-140 & MK-677 by SARMs Rx
Testolone & Nutrobal Stack: RAD-140 & MK-677 by SARMs Rx
Testolone & Nutrobal Stack: RAD-140 & MK-677 by SARMs Rx
Testolone & Nutrobal Stack: RAD-140 & MK-677 by SARMs Rx
Testolone & Nutrobal Stack: RAD-140 & MK-677 by SARMs Rx

Testolone & Nutrobal Stack: RAD-140 & MK-677 by SARMs Rx

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Description

This is a combination of SARMs (Selective-Androgen-Receptor-Modulators) RAD-140 and MK-677. This is a unique combination as Testolone (RAD-140) is a traditional SARM that works on androgen receptors just like testosterone and Nutrobal is a human Growth Hormone secretagogue that works on the pituitary gland and hgH pathway.

 

These SARMs are in a PEG (Polyethylene Glycol Solution) please inquire about any allergies.

 

MK-677

Classified as a SARM, Selective-Androgen-Receptor-Modulator, MK-677 is actually not actually an androgen modulator, it is actually a Human Growth Hormone secretagogue. This means that MK-677 actually has the ability to interact with the pitutary gland to secrete hGH. While this is still an experimental compound that is not intended for consumption, there is much promise in it's ability to selectively bind the pituitary gland - minimizing negative side effects from binding other tissues.

 

Concentration

50mg/mL

 

Typical Dose Used

25mg (0.5mL) per day

It is recommended to add the SARMs into juice or a shake directly with dropper when administering doses.

 

Amount

Available in 30mL or 60mL amounts

Typical cycle lasts 5-8 weeks

 

Half-Life

24 Hours

 

 

RAD-140

RAD-140 is an experimental selective androgen receptor modulator that has an anabolic to androgenic ratio of 90:1- meaning it has almost the same anabolic effects of pure testosterone with 1/100th of the androgenic side effects (testosterone has a rating of 100:100).  This is a positive as most of the negative side effects of testosterone, including effects on liver, kidney and prostate, come from its androgenic effects while making it the most potent anabolic SARM discovered to date!

 

Concentration

10mg/mL

It is recommended to add the SARMs into juice or a shake directly with dropper when administering doses.

 

Typical Dose Used

10mg (1.0mL) per day

 

Amount

Available in 30mL or 60mL amounts

Typical cycle is 8 weeks

 

Half-Life

16 Hours

 

PCT?


Due to the potency of RAD-140 we do recommend using a Post cycle therapy due to very mild testosterone suppression. You can get ours here which is a tri-phase PCT that includes: Natural Testosterone Boosting Complex, Anti-Estrogen Complex, and a Liver detox blend.

 

 

All our SARM's are laboratory tested and we publish the certificates of analysis to ensure our product quality. We have strict standards for the specifications of our products and they are not released to the public without meeting these specs. The Certificates of Analysis are available on the bottom of each SARM page for the lot of available of that product.

 

 

Disclaimer: SARMs Rx products are furnished for LABORATORY RESEARCH USE ONLY. This product should only be handled by qualified, and licensed professionals. The product may not be used as a drug, agricultural or pesticidal product, food additive or household chemical – and may not be misbranded as such. All information on this website is available for educational purposes only. Bodily introduction of any kind into humans and/or animals is strictly forbidden by law.

Experimental Benefits

MK-677 has shown experimental benefits associated with hGH increases. This includes

  • Increase in Fat-Free Mass
  • Enhanced Sleep Quality
  • Enhanced Muscle, Bone & Ligament Recovery
  • Lowered LDL Cholesterol
  • Improved Hair & Skin Appearance

 

MK-677 has also shown it does not cause pituitary sensitization and it does not cause suppression of Growth Hormone by the body. It is also not associated with testosterone so this eliminates the chances of aromatization to estrogen, liver, kidney, or prostate danger

 

RAD-140 has shown experimental benefits associated with increases in testosterone. This includes

  • Increase in Fat-Free Mass
  • Easily beats other compounds such as LGD-4033 and MK-2866 when it comes to Building Mass & Strength.
  • Enhanced Muscle, Bone & Ligament Recovery
  • Increased Libido

 

RAD-140 has also shown  no effects on liver, kidneys, prostate, nor aromatase conversion (conversion of testosterone into estrogen). RAD-140 has been reported to cause potentially cause testosterone production suppression we recommend following with a post-cycle therapy once experimental doses have been administered. See here

 

What Are SARM's

Selective-Androgen-Receptor-Modulators are just that, they selectively bind androgen receptors. The idea behind these compounds are great; create a compound that binds androgen receptors on only muscle tissue and nowhere else. One of the biggest problems with androgens are the negative side effects from the androgen binding receptors in different places on the body such as your prostate or liver which can cause overgrowth or even increase the chance of cancer. So, SARMs are attempting to negate that by being compounds that only bind androgen receptors on muscle tissue (that's the Selective part)- you get growth in your muscle but not in other organs.

 

These are experimental compounds which have not been deemed approved for consumption, but they are avaialble for research purpose. Take a look at the science listed to get an idea!

The Science

MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism

"In conclusion, MK-677 reverses diet-induced nitrogen wasting, suggesting that if these short-term anabolic effects are maintained in patients who are catabolic because of certain acute or chronic disease states, it may be useful in treating catabolic conditions."

Source: https://doi.org/10.1210/jcem.83.2.4551

 

Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial

"Daily MK-677 significantly increased GH and IGF-I levels to those of healthy young adults without serious adverse effects."

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757071/

 

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects

"Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular disease. The stimulatory effects on the GH-insulin-like growth factor I (IGF-I) axis of orally administered MK-677, a GH-releasing peptide mimetic, were investigated. Thirty-two healthy subjects (15 women and 17 men, aged 64-81 yr) were enrolled in a randomized, double blind, placebo-controlled trial. They received placebo or 2, 10, or 25 mg MK-677, orally, once daily for 2 separate study periods of 14 and 28 days. At baseline and on day 14 of each study period, blood was collected every 20 min for 24 h to measure GH, PRL, and cortisol. Attributes of pulsatile GH release were assessed by 3 independent algorithms. MK-677 administration for 2 weeks increased GH concentrations in a dose-dependent manner, with 25 mg/day increasing mean 24-h GH concentration 97 +/- 23% (mean +/- SE; P < 0.05 vs. baseline). This increase was due to an enhancement of preexisting pulsatile GH secretion. GH pulse height and interpulse nadir concentrations increased significantly without significant changes in the number of pulses. With 25 mg/day MK-677 treatment, mean serum IGF-I concentrations increased into the normal range for young adults (141 +/- 21 microgram/L at baseline, 219 +/- 21 micrograms/L at 2 weeks, and 265 +/- 29 micrograms/L at 4 weeks; P < 0.05). MK-677 produced significant increases in fasting glucose (5.4 +/- 0.3 to 6.8 +/- 0.4 mmol/L at 4 weeks; P < 0.01 vs. baseline) and IGF-binding protein-3. Circulating cortisol concentrations did not change, and PRL concentrations increased 23%, but remained within the normal range. Once daily treatment of older people with oral MK-677 for up to 4 weeks enhanced pulsatile GH release, significantly increased serum GH and IGF-I concentrations, and, at a dose of 25 mg/day, restored serum IGF-I concentrations to those of young adults. "

Source: 10.1210/jcem.81.12.8954023 

 

Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats

"RAD140 was shown to exhibit peripheral tissue-specific androgen action that largely spared prostate, neural efficacy as demonstrated by activation of androgenic gene regulation effects, and neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate. These novel findings demonstrate initial preclinical efficacy of a SARM in neuroprotective actions relevant to Alzheimer's disease and related neurodegenerative diseases."

Source: 10.1210/en.2013-1725

 

Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats

"Together these studies provide complementary evidence that androgens regulate adult neurogenesis in the hippocampus via the AR but at a site other than the dentate gyrus. Understanding where in the brain androgens act to increase the survival of new neurons in the adult brain may have implications for neurodegenerative disorders."

Source: https://doi.org/10.1210/en.2013-1129

 

Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor–Positive Breast Cancer Models with a Distinct Mechanism of Action

"RAD140 is a potent AR agonist in breast cancer cells with a distinct mechanism of action, including the AR-mediated repression of ESR1. It inhibits the growth of multiple AR/ER+ breast cancer PDX models as a single agent, and in combination with palbociclib. The preclinical data presented here support further clinical investigation of RAD140 in AR/ER+ breast cancer patients."

Source: 10.1158/1078-0432.CCR-17-0670

Certificate of Analysis

MK677

Certificate of Analysis

Rad-140 CoA