Garcinia Cambogia is the #1 selling natural weight loss compound for good reason; because it has been proven to work while carrying benefits to overall wellness as well. A citrus fruit found in southeast Asia, Garcinia Cambogia actually contains a highly active compound in suppressing appetite, preventing the formation of fat tissue, and assisting in metabolism of carbohydrates and fats. This highly effective weight loss compound, known as hydroxycitric acid (HCA), is extracted from the rind of the fruit which we have standardized to 95% Hydroxycitric Acid Content- that’s as pure as you’re going to get it! This rivals other current versions you will find which contain a much lower concentration of HCA due to the expensive cost to isolate. Not to mention, many people only pay attention to Garcinia Cambogia extract doses instead of the active ingredient content (HCA) when looking for one to supplement with. Luckily, you’ve found the right place as we packed in 1400mg of Garcinia Cambogia per serving and standardized it to 95% HCA!
While the exact science behind the weight reduction tied to HCA is not completely understood, it is believed that the results can be contributed to it's ability to work on an enzyme in your body called ATP Citrate Lyase. This enzyme converts citrate(an intermediate in carbohydrate metabolism) to acetyl CoA (required for synthesis of fatty acids). Having readily available acetyl CoA can help drive the synthesis of fatty acids, leading to the metabolism of fat stored on your body. HCA is known as a competitive inhibitor of this enzyme which is what is believed to alter the way your body metabolizes and stores fat.
This article is an overview of Garcinia Cambogia that brings in a bunch of different independent studies and summarizes the findings. In the abstract, this article details the role of Hydroxycitric Acid in regards to ATP Citrate Lyase. The findings of this article states:
“HCA is a potent inhibitor of adenosine triphosphate-citrate lyase, a catalyst for the conversion process of citrate to acetyl-coenzyme A, which plays a key role in fatty acid, cholesterol and triglycerides syntheses. The crude extract or constituents from the plant also exerted hypolipidaemic, antidiabetic, anti-inflammatory, anticancer, anthelmintic, anticholinesterase and hepatoprotective activities in in vitro and in vivo models”
Citation: Semwal, R. B., Semwal, D. K., Vermaak, I., & Viljoen, A. (2015). A comprehensive scientific overview of Garcinia cambogia. Fitoterapia, 102, 134–148. doi: 10.1016/j.fitote.2015.02.012
This article not only touches on the weight loss effects of several studies using Garcinia Cambogia, but actually tests the safety of supplementing with high doses of Hydroxycitric Acid. According to this article, a study conducted with 873 participants with certain groups dosing up to 2800mg/day of HCA saw no negative health effects:
“Based on the results obtained in an array of toxicological and safety studies, a comprehensive safety profile on G. cambogia extract/HCA as dietary supplements for treating obesity has been established [41, 42, 66, 70] (Table 2). Cytotoxicity study , genotoxicity study [22, 23], acute toxicity studies (such as acute oral, acute dermal, primary dermal irritation, and primary eye irritation toxicity studies) [11, 12], sub-chronic 90-day safety study [15, 24, 25], two-generation reproductive and teratogenicity studies [24, 25, 36–40], and clinical studies on G. cambogia extract/HCA [43–58] support its safety demonstrating a wide margin of safety for human consumption.”
Citation: Chuah, L. O., Yeap, S. K., Ho, W. Y., Beh, B. K., & Alitheen, N. B. (2012). In VitroandIn VivoToxicity ofGarciniaor Hydroxycitric Acid: A Review. Evidence-Based Complementary and Alternative Medicine, 2012, 1–12. doi: 10.1155/2012/197920
This study showed that Hydroxycitric acid was effective and safe as a weight-loss formula after a double-blind placebo study supplementing with HCA in 60 participants:
“The present study shows that optimal doses of HCA‐SX and, to a greater degree, the combination of HCA‐SX, NBC and GSE can serve as an effective and safe weight‐loss formula that can facilitate a reduction in excess body weight and BMI, while promoting healthy blood lipid levels.”
Citation: Preuss, H. G., Bagchi, D., Bagchi, M., Rao, C. V. S., Dey, D. K., & Satyanarayana, S. (2004). Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes, Obesity and Metabolism, 6(3), 171–180. doi: 10.1111/j.1462-8902.2004.00328.x
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